The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

Reinforcement learning models postulate that neurons that release dopamine encode
information about action and action outcome, and provide a teaching signal to striatal spiny …

Substantia nigra dopamine neurons have been implicated in the initiation and invigoration
of movement, presumably through their modulation of striatal projection neuron (SPN) …

The canonical model of striatal function predicts that animal locomotion is associated with
the opposing regulation of protein kinase A (PKA) in direct and indirect pathway striatal …

Abstract cAMP is a key second messenger that regulates diverse cellular functions including
neural plasticity. However, the spatiotemporal dynamics of intracellular cAMP in intact …

Cyclic adenosine monophosphate (cAMP) signaling integrates information from diverse G-
protein-coupled receptors, such as neuromodulator receptors, to regulate pivotal biological …

Seeking new insights into the homeostasis, modulation and plasticity of cortical synaptic
networks, we have analyzed results from a single-cell RNA-seq study of 22,439 mouse …

Protein kinases control nearly every facet of cellular function. These key signaling nodes
integrate diverse pathway inputs to regulate complex physiological processes, and aberrant …

The axon is responsible for integrating synaptic signals, generating action potentials (APs),
propagating those APs to downstream synapses and converting them into patterns of …