Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts
The discovery of immune checkpoint inhibitors (ICIs) has now been universally
acknowledged as a significant breakthrough in tumor therapy after the targeted treatment of …
acknowledged as a significant breakthrough in tumor therapy after the targeted treatment of …
The Hippo signalling pathway and its implications in human health and diseases
M Fu, Y Hu, T Lan, KL Guan, T Luo… - Signal transduction and …, 2022 - nature.com
As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …
the regulation of numerous biological processes. Thus, substantial efforts have been made …
Persistent mutation burden drives sustained anti-tumor immune responses
Tumor mutation burden is an imperfect proxy of tumor foreignness and has therefore failed
to consistently demonstrate clinical utility in predicting responses in the context of …
to consistently demonstrate clinical utility in predicting responses in the context of …
Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the …
A Marabelle, M Fakih, J Lopez, M Shah… - The Lancet …, 2020 - thelancet.com
Background Tumour mutational burden (TMB) has been retrospectively correlated with
response to immune checkpoint blockade. We prospectively explored the association of …
response to immune checkpoint blockade. We prospectively explored the association of …
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
R Cunningham, CG Hansen - Clinical Science, 2022 - portlandpress.com
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …
signalling pathways. One such pathway that has garnered much attention in the field of …
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …
organ development, epithelial homeostasis, tissue regeneration, wound healing and …
Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
Antitumoral immunity requires organized, spatially nuanced interactions between
components of the immune tumor microenvironment (iTME). Understanding this coordinated …
components of the immune tumor microenvironment (iTME). Understanding this coordinated …
Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
Ferroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid
peroxidation, has been implicated in diseases such as ischaemic organ damage and …
peroxidation, has been implicated in diseases such as ischaemic organ damage and …
Deep learning-based classification of mesothelioma improves prediction of patient outcome
Malignant mesothelioma (MM) is an aggressive cancer primarily diagnosed on the basis of
histological criteria. The 2015 World Health Organization classification subdivides …
histological criteria. The 2015 World Health Organization classification subdivides …
Perspectives on the treatment of malignant pleural mesothelioma
Mesothelioma Most mesotheliomas originate in the pleura and are due to asbestos
exposure. The incidence is decreasing somewhat with asbestos remediation, but mortality …
exposure. The incidence is decreasing somewhat with asbestos remediation, but mortality …