iPSC-derived cardiomyocytes in inherited cardiac arrhythmias: pathomechanistic discovery and drug development

E Simons, B Loeys, M Alaerts - Biomedicines, 2023 - mdpi.com
With the discovery of induced pluripotent stem cell (iPSCs) a wide range of cell types,
including iPSC-derived cardiomyocytes (iPSC-CM), can now be generated from an …

Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome

G Nasilli, L Yiangou, C Palandri, E Cerbai, RP Davis… - Europace, 2023 - academic.oup.com
Aims SCN5A mutations are associated with various cardiac phenotypes, including long QT
syndrome type 3 (LQT3), Brugada syndrome (BrS), and cardiac conduction disease (CCD) …

Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives

WH Wang, ZR Li, DX Zhu, JY Chen… - Pest Management …, 2024 - Wiley Online Library
BACKGROUND Xanthomonas oryzae pv. oryzae (Xoo) is often considered one of the most
destructive bacterial pathogens causing bacterial leaf blight (BLB), resulting in significant …

ARumenamides: A novel class of potential antiarrhythmic compounds

M Abdelsayed, D Page, PC Ruben - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Most therapeutics targeting cardiac voltage-gated sodium channels (Nav1. 5)
attenuate the sodium current (INa) conducted through the pore of the protein. Whereas these …

[PDF][PDF] Reengineering Mexiletine by chemical synthesis to decrease toxicity and improve pharmacological properties with patient-derived iPSC cardiomyocytes. Arch

JR Cashman - Clin. Toxicol, 2022 - probiologists.com
Heart disease is one of the top causes of healthcare expenses in the United States. Lethal
ventricular cardiac arrhythmia can arise in acquired or congenital heart disease. Long QT …