The desired mechanical and biological performances of collagen that have led to its broad
application as a building block in the biomedical field attributed to its intrinsic hierarchical …

Fibrous connective tissues provide mechanical support and frameworks for other tissues of
the body and play an integral role in normal tissue physiology and pathology. Three …

Cell migration through 3D tissue depends on a physicochemical balance between cell
deformability and physical tissue constraints. Migration rates are further governed by the …

In native states, animal cells of many types are supported by a fibrous network that forms the
main structural component of the ECM. Mechanical interactions between cells and the 3D …

Multiple attributes of the three-dimensional (3D) extracellular matrix (ECM) have been
independently implicated as regulators of cell motility, including pore size, crosslink density …

The multistep process of cell migration requires cells to dynamically couple to extracellular
interfaces and generate traction force or friction for displacement of the cell body. When …

When cells come in contact with an adhesive matrix, they begin to spread and migrate with a
speed that depends on the stiffness of the extracellular matrix. On a flat surface, migration …

The mechanical properties of the extracellular matrix (ECM)–a complex, 3D, fibrillar scaffold
of cells in physiological environments–modulate cell behavior and can drive tissue …

Type I collagen gels are routinely used in biophysical studies and bioengineering
applications. The structural and mechanical properties of these fibrillar matrices depend on …

The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …