Intrinsically disordered proteins (IDPs) are proteins that lack rigid 3D structure. Hence, they
are often misconceived to present a challenge to Anfinsen's dogma. However, IDPs exist as …

H-Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell
proliferation, differentiation, and survival, and their mutants occur frequently in human …

Mutations in K-Ras are involved in a large number of all human cancers, thus, K-Ras is
regarded as a promising target for anticancer drug design. Understanding the target roles of …

RHOA mutations are found at diverse residues in various cancer types, implying mutation-
and cell-specific mechanisms of tumorigenesis. Here, we focus on the underlying …

Structures of wild-type K-Ras from crystals obtained in the presence of guanosine
triphosphate (GTP) or its analogs have remained elusive. Of the K-Ras mutants, only K …

Uncovering molecular basis with regard to the conformational change of two switches I and
II in the GppNHp (GNP)-bound H-Ras is highly significant for the understanding of Ras …

Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high
interest for elucidating the mechanisms by which RAS proteins interact with effectors and …

K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most
prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to …

It has recently been proposed by Gunasakaran et al. that allostery may be an intrinsic
property of all proteins. Here, we develop a computational method that can determine and …

K-Ras is the most frequently mutated protein in human cancers. However, until very recently,
its oncogenic mutants were viewed as undruggable. To develop inhibitors that directly target …