Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Purpose To demonstrate the feasibility of identifying a germline RB1 pathogenic variant in
retinoblastoma (RB) from an aqueous humor (AH) sample. Methods In this pilot case series …

Cancer, being the most formidable ailment, has had a profound impact on the human health.
The disease is primarily associated with genetic mutations that impact oncogenes and tumor …

Retinoblastoma is the most frequent intraocular malignant tumor type to occur in childhood.
MicroRNA (miR)‑101‑3p has been reported to function as a tumor suppressor in various …

Purpose Retinoblastoma (RB) is a retinal tumor that most commonly occurs in children.
Approximately 40% of RB patients carry germline mutations in the RB1 gene. RB survivors …

Background India accounts for 20% of the global retinoblastoma (RB) burden. However, the
existing data on RB1 gene germline mutations and its influence on clinical decisions is …

Abstract Introduction: Pakistan, Indonesia, Bangladesh and the Philippines are listed as
among the six Asian countries which will be the sources of 43% or almost 4000 new cases …

The aim of this study was to evaluate the effects of miR-26a on Beclin 1 expression in
retinoblastoma (RB) cell lines (Y79 and WERi-RB-1). RB cells were transfected with miR …

BACKGROUND Retinoblastoma (RB) is an inherited disorder caused by the RB1 gene
mutation in retinal cells or germline mutation. Identifying the specific mutation is crucial for …

The prevalence of eye diseases worldwide is dramatically increasing and represents a
major concern in underdeveloped and developed regions. Ocular diseases, previously …