The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …

In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Functional bowel disorders are highly prevalent disorders found worldwide. These disorders
have the potential to affect all members of society, regardless of age, sex, race, creed, color …

Communication between the brain and gut is not one-way, but a bidirectional highway
whereby reciprocal signals between the two organ systems are exchanged to coordinate …

Abstract Background The first British Dietetic Association (BDA) guidelines for the dietary
management of irritable bowel syndrome (IBS) in adults were published in 2012 …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints
arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity …

Topical capsaicin formulations are used for pain management. Safety and modest efficacy of
low-concentration capsaicin formulations, which require repeated daily self-administration …

A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …

Functional gastrointestinal disorders (FGIDs) have been re-named as disorders of gut-brain
interactions. These conditions are not only common in clinical practice, but also in the …