Diffuse large B-cell lymphoma

S Li, KH Young, LJ Medeiros - Pathology, 2018 - Elsevier
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma
worldwide, representing approximately 30–40% of all cases in different geographic regions …

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

Q Qu, F Zeng, X Liu, QJ Wang, F Deng - Cell death & disease, 2016 - nature.com
Tumor cells exhibit unique metabolic adaptations that are increasingly viewed as potential
targets for novel and specific cancer therapies. Among these targets, the carnitine …

Detection of early seeding of Richter transformation in chronic lymphocytic leukemia

F Nadeu, R Royo, R Massoni-Badosa… - Nature medicine, 2022 - nature.com
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia
(CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The …

The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma

CB Steen, BA Luca, MS Esfahani, A Azizi, BJ Sworder… - Cancer cell, 2021 - cell.com
Biological heterogeneity in diffuse large B cell lymphoma (DLBCL) is partly driven by cell-of-
origin subtypes and associated genomic lesions, but also by diverse cell types and cell …

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

B Chapuy, C Stewart, AJ Dunford, J Kim, A Kamburov… - Nature medicine, 2018 - nature.com
Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is
a clinically and genetically heterogeneous disease that is further classified into …

Genetic and functional drivers of diffuse large B cell lymphoma

A Reddy, J Zhang, NS Davis, AB Moffitt, CL Love… - Cell, 2017 - cell.com
Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is
characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity …

Clinical and biological subtypes of B-cell lymphoma revealed by microenvironmental signatures

N Kotlov, A Bagaev, MV Revuelta, JM Phillip… - Cancer discovery, 2021 - AACR
Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous
disease. Transcriptomic and genetic characterization of DLBCL has increased the …

Targetable genetic features of primary testicular and primary central nervous system lymphomas

B Chapuy, MGM Roemer, C Stewart… - Blood, The Journal …, 2016 - ashpublications.org
Primary central nervous system lymphomas (PCNSLs) and primary testicular lymphomas
(PTLs) are extranodal large B-cell lymphomas (LBCLs) with inferior responses to current …

Common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma

J Chaisaingmongkol, A Budhu, H Dang… - Cancer cell, 2017 - cell.com
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically
disparate primary liver cancers with etiological and biological heterogeneity. We identified …

Similarities and distinctions of cancer and immune metabolism in inflammation and tumors

G Andrejeva, JC Rathmell - Cell metabolism, 2017 - cell.com
It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from
resting tissues. More recently understood is that this metabolic phenotype is not unique to …