Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration

MM LaVail, S Nishikawa, RH Steinberg… - Experimental eye …, 2018 - Elsevier
We produced 8 lines of transgenic (Tg) rats expressing one of two different rhodopsin
mutations in albino Sprague-Dawley (SD) rats. Three lines were generated with a proline to …

Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats' model

Y Wang, S Qin, G Pen, D Chen, C Han… - Experimental …, 2017 - journals.sagepub.com
Ocular complications associated with diabetes mellitus are progressive and becoming one
of the most important causes of morbidity worldwide. The purpose of the study is to evaluate …

Epigallocatechin gallate slows retinal degeneration, reduces oxidative damage, and modifies circadian rhythms in P23H rats

L Perdices, L Fuentes-Broto, F Segura, N Cuenca… - Antioxidants, 2020 - mdpi.com
Retinitis pigmentosa (RP) includes a group of genetic disorders that involve the loss of
visual function due to mutations mainly in photoreceptors but also in other retinal cells …

Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

L Perdices, L Fuentes-Broto, F Segura… - Neural regeneration …, 2022 - journals.lww.com
Retinitis pigmentosa (RP) is a group of inherited retinal disorders that lead to photoreceptor
loss. RP has been reported to be related to oxidative stress, autophagy, and inflammation.(-) …

Using optical coherence tomography and optokinetic response as structural and functional visual system readouts in mice and rats

M Dietrich, C Hecker, A Hilla, A Cruz-Herranz… - JoVE (Journal of …, 2019 - jove.com
Optical coherence tomography (OCT) is a fast, non-invasive, interferometric technique
allowing high-resolution retinal imaging. It is an ideal tool for the investigation of processes …

Effects of daily melatonin supplementation on visual loss, circadian rhythms, and hepatic oxidative damage in a rodent model of retinitis pigmentosa

L Fuentes-Broto, L Perdices, F Segura… - Antioxidants, 2021 - mdpi.com
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized
by a progressive loss of visual function that primarily affect photoreceptors, resulting in the …

Spatiotemporal contrast sensitivity of Brown-Norway rats under scotopic and photopic illumination

NP Johnson, SM Gregorich, CL Passaglia - Neuroscience, 2020 - Elsevier
Rats are a popular animal model for vision research and for investigating disorders of the
visual system. The study aimed to quantify the spatiotemporal contrast sensitivity function …

Retinal responses to visual stimuli in interphotoreceptor retinoid binding-protein knock-out mice

ML DeRamus, JV Jasien, JM Eppstein, P Koala… - International journal of …, 2023 - mdpi.com
Interphotoreceptor retinoid-binding protein (IRBP) is an abundant glycoprotein in the
subretinal space bound by the photoreceptor (PR) outer segments and the processes of the …

Optical Coherence Tomography: Imaging Visual System Structures in Mice

X Liu, Y Liu, RK Lee - Retinal Ganglion Cells: Methods and Protocols, 2023 - Springer
Optical coherence tomography (OCT) enables micron-scale resolution of structural anatomy,
thereby making OCT a valuable tool for addressing ophthalmologic and neurologic …

[引用][C] 表没食子儿茶素没食子酸酯减轻色素性视网膜炎视网膜变性的作用机制

L Perdices, L Fuentes-Broto, F Segura, A Cavero - 中国神经再生研究(英文版), 2022