PTB: Not just a polypyrimidine tract‐binding protein

S Dai, C Wang, C Zhang, L Feng… - Journal of Cellular …, 2022 - Wiley Online Library
Polypyrimidine tract‐binding protein (PTB), as a member of the heterogeneous nuclear
ribonucleoprotein family, functions by rapidly shuttling between the nucleus and the …

New insights into functional roles of the polypyrimidine tract-binding protein

MG Romanelli, E Diani, PMJ Lievens - International journal of molecular …, 2013 - mdpi.com
Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein
involved in several post-transcriptional regulatory events of gene expression. Initially …

[HTML][HTML] Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits

Y Xue, K Ouyang, J Huang, Y Zhou, H Ouyang, H Li… - Cell, 2013 - cell.com
The induction of pluripotency or trans-differentiation of one cell type to another can be
accomplished with cell-lineage-specific transcription factors. Here, we report that repression …

Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4+ T Cells

KG Lassen, KX Ramyar, JR Bailey, Y Zhou… - PLoS …, 2006 - journals.plos.org
HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in
patients on highly active antiretroviral therapy (HAART). We describe here a novel post …

Regulation of pluripotency by RNA binding proteins

J Ye, R Blelloch - Cell stem cell, 2014 - cell.com
Establishment, maintenance, and exit from pluripotency require precise coordination of a
cell's molecular machinery. Substantial headway has been made in deciphering many …

Post‐transcriptional regulatory networks in immunity

P Ivanov, P Anderson - Immunological reviews, 2013 - Wiley Online Library
Post‐transcriptional mechanisms that modulate global and/or transcript‐specific m RNA
stability and translation contribute to the rapid and flexible control of gene expression in …

Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro

X He, M Pool, KM Darcy, SB Lim, N Auersperg… - Oncogene, 2007 - nature.com
Polypyrimidine tract-binding protein (PTB) is an RNA-binding protein with multiple functions
in the regulation of RNA processing and IRES-mediated translation. We report here …

Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer

X He, AD Arslan, MD Pool, TT Ho, KM Darcy, JS Coon… - Oncogene, 2011 - nature.com
Our previous study revealed that two splicing factors, polypyrimidine tract-binding protein
(PTB) and SRp20, were upregulated in epithelial ovarian cancer (EOC) and knockdown of …

The polypyrimidine tract-binding protein affects coronavirus RNA accumulation levels and relocalizes viral RNAs to novel cytoplasmic domains different from …

I Sola, C Galán, PA Mateos-Gómez, L Palacio… - Journal of …, 2011 - Am Soc Microbiol
The coronavirus (CoV) discontinuous transcription mechanism is driven by long-distance
RNA-RNA interactions between transcription-regulating sequences (TRSs) located at the …

Polypyrimidine tract‐binding protein is essential for early mouse development and embryonic stem cell proliferation

M Shibayama, S Ohno, T Osaka, R Sakamoto… - The FEBS …, 2009 - Wiley Online Library
Polypyrimidine tract‐binding protein (PTB) is a widely expressed RNA‐binding protein with
multiple roles in RNA processing, including the splicing of alternative exons, mRNA stability …