Neuronal voltage-gated calcium channels: structure, function, and dysfunction

BA Simms, GW Zamponi - Neuron, 2014 - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology

AC Dolphin - The Journal of physiology, 2016 - Wiley Online Library
Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

[HTML][HTML] Calcium channel regulation and presynaptic plasticity

WA Catterall, AP Few - Neuron, 2008 - cell.com
Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …

[HTML][HTML] Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

S Heyes, WS Pratt, E Rees, S Dahimene, L Ferron… - Progress in …, 2015 - Elsevier
This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …

Calcium sparks

H Cheng, WJ Lederer - Physiological reviews, 2008 - journals.physiology.org
The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Calmodulin regulation (calmodulation) of voltage-gated calcium channels

M Ben-Johny, DT Yue - Journal of General Physiology, 2014 - rupress.org
Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels
comprises a prominent prototype for ion channel regulation, remarkable for its powerful …

Supramolecular assemblies and localized regulation of voltage-gated ion channels

S Dai, DD Hall, JW Hell - Physiological reviews, 2009 - journals.physiology.org
This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases …

Decoding cytosolic Ca2+ oscillations

AB Parekh - Trends in biochemical sciences, 2011 - cell.com
A rise in cytosolic Ca 2+ concentration is used as a universal signalling mechanism to
control biological processes as diverse as exocytosis, contraction, cell growth and cell …

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular …

WB Limpitikul, IE Dick, R Joshi-Mukherjee… - Journal of molecular and …, 2014 - Elsevier
Recent work has identified missense mutations in calmodulin (CaM) that are associated with
severe early-onset long-QT syndrome (LQTS), leading to the proposition that altered CaM …

Voltage-gated calcium channels: key players in sensory coding in the retina and the inner ear

T Pangrsic, JH Singer, A Koschak - Physiological reviews, 2018 - journals.physiology.org
Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …