The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one of the most
frequently deregulated driver genes in human cancer. Because of its high prevalence of …

RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS
being the most frequently mutated and MYC the most amplified. The cooperative interplay …

Gene activation requires the cooperative activity of multiple transcription factors at cis-
regulatory elements (CREs). Yet, most transcription factors have short residence time …

The oncogene Myc is deregulated in the majority of human tumors and drives numerous
hallmarks of cancer. Despite its indisputable role in cancer development and maintenance …

Abstract c-Myc is a transcription factor that is constitutively and aberrantly expressed in over
70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression …

Igf2bp1 is an oncofetal RNA binding protein whose expression in numerous types of
cancers is associated with upregulation of key pro-oncogenic RNAs, poor prognosis, and …

Vitamin D is a steroid hormone crucial for bone mineral metabolism. In addition, vitamin D
has pleiotropic actions in the body, including anti-cancer actions. These anti-cancer …

Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS).
However, the epigenetic networks underlying the maintenance of oncogenic signaling and …

Metabolic reprogramming is of great significance in the progression of various cancers and
is critical for cancer progression, diagnosis, and treatment. Cellular metabolic pathways …

The intrinsically disordered protein MYC belongs to the family of basic helix-loop-helix
leucine zipper (bHLH-LZ) transcription factors (TFs). In complex with its cognate binding …