Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB)
exists between the blood microcirculation system and the brain parenchyma. The normal …

The spike glycoprotein attached to the envelope of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) …

Multiple sclerosis (MS) is an immune-mediated and neurodegenerative disorder that results
in inflammation and demyelination of the central nervous system (CNS). MS symptoms …

Respiratory syncytial virus (RSV) is the major cause of respiratory illness in infants
worldwide. Neurologic alterations, such as seizures and ataxia, have been associated with …

Tumor inflammation, the recruitment of myeloid lineage cells into the tumor
microenvironment, promotes angiogenesis, immunosuppression and metastasis. CD11b+ …

The human JC polyomavirus (JCPyV) is the causative agent of the fatal, demyelinating
disease progressive multifocal leukoencephalopathy (PML). The Mad-1 prototype strain of …

Selective inhibition of the RGD (Arg-Gly-Asp) integrin αvβ1 has been recently identified as
an attractive therapeutic approach for the treatment of liver fibrosis given its function, target …

The pathophysiology of autoimmune disorders is multifactorial, where immune cell
migration, adhesion, and lymphocyte activation play crucial roles in its progression. These …