Osteoarthritis (OA) is the most common degenerative joint disease. In 1999, two members of
the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) family of …

Due to the necessity for more environmentally benign processes in synthetic organic
chemistry, and in particular in photocatalysis, a recourse to photocatalysts that are also …

A metal-free porphyrin covalent organic framework was employed as the heterogeneous
photocatalyst for the synthesis of tetrahydroquinolines under aerobic conditions. With visible …

Degradation of proteoglycan is the key early event in the development of osteoarthritis (OA).
The aggrecanase ADAMTS-5 has been identified as the major enzyme responsible for the …

Background Producing bioactive skeletons through direct oxidative coupling of C (sp 3)-H
bonds adjacent to heteroatoms with C (sp 2)-H alkenes bonds has become a topic of …

A synthetic strategy has been developed for pyrrolo [3, 4-c] quinoline-1, 3-diones. This
synthetic protocol consists of sequential CeO2 catalyzed oxidative annulation followed by …

Dipolar cycloadditions of different azomethine ylides to 3-nitro-2 (1H)-quinolinones were
carried out to give 3a-nitro-4-oxo-1, 2, 3, 3a, 5, 9 b-hexahydropyrrolo [3, 4-c] quinoline-4-one …

Aggrecanases, particularly aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5),
are believed to be key enzymes involved in the articular cartilage breakdown that leads to …

We developed the first one-pot synthesis of structurally diverse pyrrolo [3, 4-c] quinoline-1-
one derivatives via a three-component cascade reaction of enaminones, amines, and isatin …

Aggrecanases, in particular aggrecanase-2 (ADAMTS-5), are considered the principal
proteases responsible for aggrecan degradation in osteoarthritis. For this reason …