Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …

Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

Plastics are novel environmental pollutants with potential threats to the ecosystem. At least
5.25 trillion plastic particles in the environment, of which nanoplastics are< 100 nm in …

Copper is a crucial trace element that plays a role in various pathophysiological processes
in the human body. Copper also acts as a transition metal involved in redox reactions …

Osthole is a natural coumarin which has been proved to inhibit growth of cancer cells by
inducing cell death, while its mechanism was considered to be just caused by apoptosis. In …

Oxidative stress is a state of imbalance between oxidation and antioxidation. Excessive ROS
levels are an important factor in tumor development. Damage stimulation and excessive …

Under metabolic stress conditions such as hypoxia and glucose deprivation, an increase in
the AMP: ATP ratio activates the AMP-activated protein kinase (AMPK) pathway, resulting in …

Chronic alcohol consumption can cause alcoholic liver disease (ALD), leading to morbidity
and mortality worldwide. Complex disease progression of ALD varies from alcoholic fatty …

Cancer treatment is hampered by resistance to conventional therapeutic strategies,
including chemotherapy, immunotherapy, and targeted therapy. Redox homeostasis …