[HTML][HTML] Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling

P Tandon, F Conlon, JD Furlow, ME Horb - Developmental biology, 2017 - Elsevier
The amphibian model Xenopus, has been used extensively over the past century to study
multiple aspects of cell and developmental biology. Xenopus offers advantages of a non …

Thyroid and corticosteroid signaling in amphibian metamorphosis

B Paul, ZR Sterner, DR Buchholz, YB Shi, LM Sachs - Cells, 2022 - mdpi.com
In multicellular organisms, development is based in part on the integration of communication
systems. Two neuroendocrine axes, the hypothalamic–pituitary–thyroid and the …

Thyroid hormone regulates distinct paths to maturation in pigment cell lineages

LM Saunders, AK Mishra, AJ Aman, VM Lewis… - Elife, 2019 - elifesciences.org
Thyroid hormone (TH) regulates diverse developmental events and can drive disparate
cellular outcomes. In zebrafish, TH has opposite effects on neural crest derived pigment …

[HTML][HTML] More similar than you think: Frog metamorphosis as a model of human perinatal endocrinology

DR Buchholz - Developmental biology, 2015 - Elsevier
Hormonal control of development during the human perinatal period is critically important
and complex with multiple hormones regulating fetal growth, brain development, and organ …

Insufficiency of thyroid hormone in frog metamorphosis and the role of glucocorticoids

LM Sachs, DR Buchholz - Frontiers in Endocrinology, 2019 - frontiersin.org
Thyroid hormone (TH) is the most important hormone in frog metamorphosis, a
developmental process which will not occur in the absence of TH but can be induced …

Xenopus metamorphosis as a model to study thyroid hormone receptor function during vertebrate developmental transitions

DR Buchholz - Molecular and Cellular Endocrinology, 2017 - Elsevier
A hormone-dependent developmental transition from aquatic to terrestrial existence occurs
in all tetrapod vertebrates, such as birth, hatching, and metamorphosis. Thyroid hormones …

Tail Resorption During Metamorphosis in Xenopus Tadpoles

Y Yaoita - Frontiers in Endocrinology, 2019 - frontiersin.org
Tail resorption in anuran tadpoles is one of the most physically and physiologically notable
phenomena in developmental biology. A tail that is over twice as long as the tadpole trunk is …

Growth, Development, and Intestinal Remodeling Occurs in the Absence of Thyroid Hormone Receptor α in Tadpoles of Xenopus tropicalis

J Choi, A Ishizuya-Oka, DR Buchholz - Endocrinology, 2017 - academic.oup.com
During development in all vertebrates, thyroid hormone receptors (TRs) are expressed
before as well as during and after the peak in plasma thyroid hormone (TH) levels …

Thyroid Hormone Receptor α Controls Developmental Timing and Regulates the Rate and Coordination of Tissue-Specific Metamorphosis in Xenopus tropicalis

L Wen, Y Shibata, D Su, L Fu, N Luu, YB Shi - Endocrinology, 2017 - academic.oup.com
Abstract Thyroid hormone (T3) receptors (TRs) mediate the effects of T3 on organ
metabolism and animal development. There are two TR genes, TR α and TR β, in all …

Life without thyroid hormone receptor

YB Shi - Endocrinology, 2021 - academic.oup.com
Thyroid hormone (T3) is critical not only for organ function and metabolism in the adult but
also for animal development. This is particularly true during the neonatal period when T3 …