In this review we describe how highly addictive psychostimulants such as cocaine and
methamphetamine actions might underlie hypoexcitabilty in frontal cortical areas observed …

Parkinson's disease (PD) is a progressive neurodegenerative disease with a high
prevalence, approximately 1% in the elderly population. Numerous studies have …

Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and
animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping …

Chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in
humans and in animal models. Modafinil is a wake-promoting compound approved for the …

Amphetamine (AMPH) is an addictive psychostimulant highly used worldwide and its
consumption is related to neurotoxic effects. Currently, there is no pharmacotherapy …

IEGs play a critical functional role of in molecular, cellular, and behavioral alterations
induced by psychostimulants. IEGs appear to have specific chromatin structures that may …

Ethanol is known as an effective agent against cerebral lesions after ischemia. Modafinil is a
stimulant of the central nervous system (CNS) with antioxidant properties. We assessed the …

Although some of the clinical manifestations of substance use disorders might be
superficially similar, it is highly likely that different classes of abused drugs including opioids …

The wake-promoting drug Modafinil has been used for many years for treatment of
Narcolepsy and Excessive Daytime Sleepiness, due to a dopamine-related psychostimulant …

Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor
to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known …