Advanced light source analytical techniques for exploring the biological behavior and fate of nanomedicines

M Cao, K Zhang, S Zhang, Y Wang… - ACS Central Science, 2022 - ACS Publications
Exploration of the biological behavior and fate of nanoparticles, as affected by the
nanomaterial–biology (nano–bio) interaction, has become progressively critical for guiding …

Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles

S Roudeau, A Carmona, R Ortega - Current Opinion in Chemical Biology, 2023 - Elsevier
Chemical elements, especially metals, play very specific roles in the life sciences. The
implementation of correlative imaging methods, of elements on the one hand and of …

A bioluminescent probe for simultaneously imaging esterase and histone deacetylase activity in a tumor

C Wang, W Du, T Zhang, G Liang - Analytical Chemistry, 2020 - ACS Publications
The monitoring of esterase (CES) and histone deacetylase (HDAC) activity in living cells has
great potential for rapid diagnosis of malignant tumors. At present, using one …

Multifunctional nanoprobe for 3D nanoresolution imaging of intact cell HER2 protein with hard X-ray tomography

C Zhang, K Zhang, Y Cui, Y Guo, C Wang… - Analytical …, 2022 - ACS Publications
Three-dimensional nondestructive, nanoresolution, and in situ visualization of protein spatial
localization in a large, thick single cell remains challenging. In this study, we designed a …

De novo designed coiled coils as scaffolds for lanthanides, including novel imaging agents with a twist

AM Webster, AFA Peacock - Chemical Communications, 2021 - pubs.rsc.org
For much of their history, lanthanides were thought to be biologically inert. However, the last
decade has seen the discovery and development of the field of native lanthanide …

[PDF][PDF] Upscaling X-ray nanoimaging to macroscopic specimens

M Du, Z Di, D Gürsoy, RP Xian… - Journal of applied …, 2021 - journals.iucr.org
Upscaling X-ray nanoimaging to macroscopic specimens has the potential for providing
insights across multiple length scales, but its feasibility has long been an open question. By …

Three-dimensional imaging of grain boundaries via quantitative fluorescence X-ray tomography analysis

M Ge, X Huang, H Yan, D Gursoy, Y Meng… - Communications …, 2022 - nature.com
Three-dimensional visualization of material composition within multiple grains and across
complex networks of grain boundaries at nanoscales can provide new insight into the …

Sub-10 second fly-scan nano-tomography using machine learning

J Zhang, WK Lee, M Ge - Communications Materials, 2022 - nature.com
X-ray computed tomography is a versatile technique for 3D structure characterization.
However, conventional reconstruction algorithms require that the sample not change …

Emerging synchrotron radiation X-ray-sensitive probes for in situ bioimaging at the nanoscale

S Wang, Z Yang, X Ma, Z Zhou, Z Ma, J Chen… - TrAC Trends in Analytical …, 2024 - Elsevier
X-ray imaging technologies have developed rapidly in bioimaging due to their unparalleled
qualities such as nano-spatial resolution, three-dimensional panoramic observation, and …

In situ analysis of metallodrugs at the single-cell level based on synchrotron radiation technology

C Xu, D Xia, X Zhang, Q Yao, Y Wang… - TrAC Trends in Analytical …, 2024 - Elsevier
Many metal-based complex drugs or nanomedicines are currently being utilized for
therapeutic and diagnostic purposes in diseases. To better understand the metabolism …