Hemodynamic dysfunction in neonatal sepsis

A Kharrat, A Jain - Pediatric Research, 2022 - nature.com
Cardiovascular disturbances are a frequent occurrence in neonatal sepsis. Preterm and
term infants are particularly vulnerable due to the unique features of their cardiovascular …

[HTML][HTML] Corticosteroids in Pediatric Septic Shock: A Narrative Review

I Rulli, AM Carcione, F D'Amico, G Quartarone… - Journal of personalized …, 2024 - mdpi.com
Objective: A controversial aspect of pediatric septic shock management is corticosteroid
therapy. Current guidelines do not recommend its use in forms responsive to fluids and …

Assessment of hemodynamic dysfunction in septic newborns by functional echocardiography: a systematic review

F Pugnaloni, DU De Rose, F Kipfmueller, N Patel… - Pediatric …, 2024 - nature.com
Background Neonatal sepsis remains a leading cause of mortality in neonatal units.
Neonatologist-performed echocardiography (NPE) offers the potential for early detection of …

Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates

C Hays, G Touak, A Bouaboud, A Fouet, J Guignot… - Elife, 2019 - elifesciences.org
Group B Streptococcus (GBS) is the leading cause of invasive bacterial neonatal infections.
Late-onset diseases (LOD) occur between 7 and 89 days of life and are largely due to the …

Hydrocortisone dosing for hypotension in newborn infants: less is more

KL Watterberg - The Journal of pediatrics, 2016 - jpeds.com
Debate surrounds all aspects of hypotension in newborn infants, including the definition, the
questions of whether and when to treat it, the choice of treatments, and their possible …

Novel method of measuring chronic stress for preterm infants: Skin cortisol

AL D'Agata, MB Roberts, T Ashmeade… - …, 2019 - Elsevier
Background and objectives Infants who begin life in the medicalized environment of the
neonatal intensive care unit (NICU) do so under stressful conditions. Environmental …

Comparative profiling of adrenal steroids in maternal and umbilical cord blood

S Travers, L Martinerie, P Boileau, QY Xue… - The Journal of Steroid …, 2018 - Elsevier
Fetal steroidome in late pregnancy receives multiple contributions from both maternal and
fetal adrenals as well as from placenta. Depressed glucocorticoid levels have been reported …

Multiple adrenocortical steroid response to administration of exogenous adrenocorticotropic hormone to hospitalized foals

KA Dembek, LM Johnson, KJ Timko… - Journal of veterinary …, 2019 - Wiley Online Library
Background The hypothalamic‐pituitary‐adrenal axis regulates the response to sepsis‐
associated stress. Relative adrenal insufficiency or adrenocorticotropic hormone (ACTH) …

Integrative omics to detect bacteremia in patients with febrile neutropenia

RS Kelly, J Lasky-Su, SCJ Yeung, RM Stone… - PLoS …, 2018 - journals.plos.org
Background Cancer chemotherapy-associated febrile neutropenia (FN) is a common
condition that is deadly when bacteremia is present. Detection of bacteremia depends on …

Cortisol intermediates and hydrocortisone responsiveness in critical neonatal disease

A Khashana, T Saarela, M Ramet… - The Journal of Maternal …, 2017 - Taylor & Francis
Objective: Therapy-resistant hypotension complicates diseases in neonates. Our objective
was to investigate whether lack of therapeutic response to plasma expanders and inotropes …