Covid-19: the rollercoaster of fibrin (ogen), d-dimer, von willebrand factor, p-selectin and their interactions with endothelial cells, platelets and erythrocytes
C Grobler, SC Maphumulo, LM Grobbelaar… - International journal of …, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus
disease 2019 (COVID-19)-induced infection, is strongly associated with various …
disease 2019 (COVID-19)-induced infection, is strongly associated with various …
Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism
We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …
Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases
Antiplatelet medications comprise the cornerstone of treatment for diseases that involve
arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral …
arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral …
Prothrombotic phenotype in COVID-19: focus on platelets
COVID-19 infection is associated with a broad spectrum of presentations, but alveolar
capillary microthrombi have been described as a common finding in COVID-19 patients …
capillary microthrombi have been described as a common finding in COVID-19 patients …
Temporal roles of platelet and coagulation pathways in collagen-and tissue factor-induced thrombus formation
In hemostasis and thrombosis, the complex process of thrombus formation involves different
molecular pathways of platelet and coagulation activation. These pathways are considered …
molecular pathways of platelet and coagulation activation. These pathways are considered …
Role of platelets in chronic kidney disease
Platelet-dependent mechanisms for excessive clotting and bleeding in CKD remain
undefined. Moreover, platelets' contribution to inflammation, and specifically to CKD, are …
undefined. Moreover, platelets' contribution to inflammation, and specifically to CKD, are …
Nonredundant roles of platelet glycoprotein VI and integrin αIIbβ3 in fibrin-mediated microthrombus formation
G Perrella, J Huang, I Provenzale… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Fibrin is considered to strengthen thrombus formation via integrin αIIbβ3, but
recent findings indicate that fibrin can also act as ligand for platelet glycoprotein VI …
recent findings indicate that fibrin can also act as ligand for platelet glycoprotein VI …
[HTML][HTML] Fibrin-glycoprotein VI interaction increases platelet procoagulant activity and impacts clot structure
Abstract Background The glycoprotein VI (GPVI) signaling pathway was previously reported
to direct procoagulant platelet activity through collagen binding. However, the impact of …
to direct procoagulant platelet activity through collagen binding. However, the impact of …
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors
HYF Cheung, J Zou, C Tantiwong, DI Fernandez… - Cell Calcium, 2023 - Elsevier
In platelets, elevated cytosolic Ca 2+ is a crucial second messenger, involved in most
functional responses, including shape change, secretion, aggregation and procoagulant …
functional responses, including shape change, secretion, aggregation and procoagulant …
The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders
Phenotypic associations have been reported between blood cell traits (BCTs) and a range of
neurological and psychiatric disorders (NPDs), but in most cases, it remains unclear whether …
neurological and psychiatric disorders (NPDs), but in most cases, it remains unclear whether …