Early childhood adversity, toxic stress, and the impacts of racism on the foundations of health

JP Shonkoff, N Slopen… - Annual Review of Public …, 2021 - annualreviews.org
Inequalities in health outcomes impose substantial human and economic costs on all
societies—and the relation between early adversity and lifelong well-being presents a rich …

The role of mindfulness in reducing the adverse effects of childhood stress and trauma

R Ortiz, EM Sibinga - Children, 2017 - mdpi.com
Research suggests that many children are exposed to adverse experiences in childhood.
Such adverse childhood exposures may result in stress and trauma, which are associated …

Genes, environments, and time: the biology of adversity and resilience

WT Boyce, P Levitt, FD Martinez, BS McEwen… - …, 2021 - publications.aap.org
Exposures to adverse environments, both psychosocial and physicochemical, are prevalent
and consequential across a broad range of childhood populations. Such adversity …

The lifelong effects of early childhood adversity and toxic stress

JP Shonkoff, AS Garner… - …, 2012 - publications.aap.org
This Technical Report was retired November 2021. Advances in fields of inquiry as diverse
as neuroscience, molecular biology, genomics, developmental psychology, epidemiology …

Leveraging the biology of adversity to address the roots of disparities in health and development

JP Shonkoff - Proceedings of the National Academy of …, 2012 - National Acad Sciences
Extensive evidence that personal experiences and environmental exposures are embedded
biologically (for better or for worse) and the cumulative knowledge of more than four …

Immunomodulatory effects of green tea polyphenols

S Wang, Z Li, Y Ma, Y Liu, CC Lin, S Li, J Zhan, CT Ho - Molecules, 2021 - mdpi.com
Green tea and its bioactive components, especially polyphenols, possess many health-
promoting and disease-preventing benefits, especially anti-inflammatory, antioxidant …

Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases

SL Prescott - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
The unparalleled burden of a diverse range of chronic noncommunicable diseases (NCDs)
is a major global challenge in the 21st century. Chronic low-grade inflammation is a …

Innate immune signaling in cardiac ischemia

F Arslan, DP De Kleijn, G Pasterkamp - Nature Reviews Cardiology, 2011 - nature.com
Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity
related to myocardial infarction is increasing in Western societies. Acute and chronic …

[HTML][HTML] Toll-like receptors in the pathogenesis of autoimmune diseases

AM Hosseini, J Majidi, B Baradaran… - Advanced …, 2015 - ncbi.nlm.nih.gov
Abstract Human Toll-like receptors (TLRs) are a family of transmembrane receptors, which
play a key role in both innate and adaptive immune responses. Beside of recognizing …

Negative regulatory approaches to the attenuation of Toll-like receptor signaling

MA Anwar, S Basith, S Choi - Experimental & molecular medicine, 2013 - nature.com
Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is
responsible for eradicating invading microorganisms through the induction of inflammatory …