An overview of cancer treatment modalities

Z Abbas, S Rehman - Neoplasm, 2018 - books.google.com
Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

A genomic and functional inventory of deubiquitinating enzymes

SMB Nijman, MPA Luna-Vargas, A Velds… - Cell, 2005 - cell.com
Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory
event, and the enzymes catalyzing these modifications have been the focus of many studies …

[HTML][HTML] Toward a comprehensive map of the effectors of rab GTPases

AK Gillingham, R Sinka, IL Torres, KS Lilley, S Munro - Developmental cell, 2014 - cell.com
Summary The Rab GTPases recruit peripheral membrane proteins to intracellular
organelles. These Rab effectors typically mediate the motility of organelles and vesicles and …

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

PA Pérez-Mancera, AG Rust, L Van Der Weyden… - Nature, 2012 - nature.com
Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much
progress concerning its molecular characterization. PDA tumours harbour four signature …

Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway

AK Classen, KI Anderson, E Marois, S Eaton - Developmental cell, 2005 - cell.com
The mechanisms that order cellular packing geometry are critical for the functioning of many
tissues, but they are poorly understood. Here, we investigate this problem in the developing …

La FAM fatale: USP9X in development and disease

M Murtaza, LA Jolly, J Gecz, SA Wood - Cellular and molecular life …, 2015 - Springer
Deubiquitylating enzymes (DUBs), act downstream of ubiquitylation. As such, these post-
post-translational modifiers function as the final arbitrators of a protein substrate's …

The ins and outs of E-cadherin trafficking

DM Bryant, JL Stow - Trends in cell biology, 2004 - cell.com
One way of controlling the activity of E-cadherin–a protein that is, simultaneously, a major
cell-adhesion molecule, a powerful tumour suppressor, a determinant of cell polarity and a …

DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

S Hussain, Y Zhang, P Galardy - Cell cycle, 2009 - Taylor & Francis
It is increasingly apparent that ubiquitin (Ub) mediated events are critical in cell proliferation.
With much attention placed on the ubiquitin-proteasome pathway as a target for …

Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains

AK Al-Hakim, A Zagorska, L Chapman… - Biochemical …, 2008 - portlandpress.com
AMPK (AMP-activated protein kinase)-related kinases regulate cell polarity as well as
proliferation and are activated by the LKB1-tumour suppressor kinase. In the present study …

Emerging roles of deubiquitinases in cancer‐associated pathways

JJ Sacco, JM Coulson, MJ Clague, S Urbé - IUBMB life, 2010 - Wiley Online Library
Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane
to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 …