Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been the focus of many studies …
AK Gillingham, R Sinka, IL Torres, KS Lilley, S Munro - Developmental cell, 2014 - cell.com
Summary The Rab GTPases recruit peripheral membrane proteins to intracellular organelles. These Rab effectors typically mediate the motility of organelles and vesicles and …
The mechanisms that order cellular packing geometry are critical for the functioning of many tissues, but they are poorly understood. Here, we investigate this problem in the developing …
Deubiquitylating enzymes (DUBs), act downstream of ubiquitylation. As such, these post- post-translational modifiers function as the final arbitrators of a protein substrate's …
One way of controlling the activity of E-cadherin–a protein that is, simultaneously, a major cell-adhesion molecule, a powerful tumour suppressor, a determinant of cell polarity and a …
S Hussain, Y Zhang, P Galardy - Cell cycle, 2009 - Taylor & Francis
It is increasingly apparent that ubiquitin (Ub) mediated events are critical in cell proliferation. With much attention placed on the ubiquitin-proteasome pathway as a target for …
AK Al-Hakim, A Zagorska, L Chapman… - Biochemical …, 2008 - portlandpress.com
AMPK (AMP-activated protein kinase)-related kinases regulate cell polarity as well as proliferation and are activated by the LKB1-tumour suppressor kinase. In the present study …
Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 …