Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Neuroblastoma is the most common extracranial solid tumor in children. One subset, high-
risk neuroblastoma, is very difficult to treat and requires multi-modal therapy. Intensification …

PURPOSE Treatment planning for children with neuroblastoma requires accurate
assessment of prognosis. The most recent Children's Oncology Group (COG) risk …

The reprogramming of a patient's immune system through genetic modification of the T cell
compartment with chimeric antigen receptors (CARs) has led to durable remissions in …

Importance Induction chemotherapy followed by high-dose therapy with autologous stem
cell transplant and subsequent antidisialoganglioside antibody immunotherapy is standard …

Background Immunotherapy with the chimeric anti-GD2 monoclonal antibody dinutuximab,
combined with alternating granulocyte-macrophage colony-stimulating factor and …

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …

Neuroblastoma is the most common extra-cranial solid tumor of childhood and the most
common in the first year of life. It is a unique malignancy in that infants often present with …

PURPOSE The combination of irinotecan, temozolomide, dintuximab, and granulocyte-
macrophage colony-stimulating factor (I/T/DIN/GM-CSF) demonstrated activity in patients …

Approximately half of the patients diagnosed with neuroblastoma are classified as having
high-risk disease. This group continues to have inadequate cure rates despite multiagent …