Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …

Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …

Objective The role of N6-methyladenosine (m6A) in tumour immune microenvironment
(TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6 …

Factor analysis decomposes single-cell gene expression data into a minimal set of gene
programs that correspond to processes executed by cells in a sample. However, matrix …

In recent years, the strategy for tumor therapy has changed from focusing on the direct killing
effect of different types of therapeutic agents on cancer cells to the new mainstream of multi …

Pancreatic cancer is characterized by an extensive fibroinflammatory microenvironment.
During carcinogenesis, normal stromal cells are converted to cytokine-high cancer …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
characterized by poor treatment response and low survival time. The current clinical …

An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic
cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and …

Apolipoprotein E (ApoE) is a multifunctional protein involved in lipid transport and
lipoprotein metabolism, mediating lipid distribution/redistribution in tissues and cells. It can …

The adult healthy human pancreas has been poorly studied given the lack of indication to
obtain tissue from the pancreas in the absence of disease and rapid postmortem …