[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …
valuable method for identifying elderly people at risk for increased vulnerability, disease …
DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina
Summary DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental
functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on …
functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on …
Distribution and function of glycosaminoglycans and proteoglycans in the development, homeostasis and pathology of the ocular surface
S Puri, YM Coulson-Thomas, TF Gesteira… - Frontiers in cell and …, 2020 - frontiersin.org
The ocular surface, which forms the interface between the eye and the external environment,
includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that …
includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that …
Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
D Karademir, V Todorova, LJA Ebner, M Samardzija… - BMC biology, 2022 - Springer
Background In inherited retinal disorders such as retinitis pigmentosa (RP), rod
photoreceptor-specific mutations cause primary rod degeneration that is followed by …
photoreceptor-specific mutations cause primary rod degeneration that is followed by …
Remodelling of the human vitreous and vitreoretinal interface–a dynamic process
TL Ponsioen, JMM Hooymans, LI Los - Progress in retinal and eye …, 2010 - Elsevier
The highly hydrated, almost acellular vitreous body of the human eye consists of only 0.1%
macromolecules, of which collagens are the most important for its matrix structure. During …
macromolecules, of which collagens are the most important for its matrix structure. During …
Heparan sulfate proteoglycans (HSPGs) of the ocular lens
TFL Wishart, FJ Lovicu - Progress in Retinal and Eye Research, 2023 - Elsevier
Heparan sulfate proteoglycans (HSPGs) reside in most cells; on their surface, in the
pericellular milieu and/or extracellular matrix. In the eye, HSPGs can orchestrate the activity …
pericellular milieu and/or extracellular matrix. In the eye, HSPGs can orchestrate the activity …
Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes
M Asai-Coakwell, CR French, M Ye… - Human molecular …, 2009 - academic.oup.com
Proteins of the bone morphogenetic protein (BMP) family are known to have a role in ocular
and skeletal development; however, because of their widespread expression and functional …
and skeletal development; however, because of their widespread expression and functional …
Ehlers-Danlos syndromes and their manifestations in the visual system
S Asanad, M Bayomi, D Brown, J Buzzard, E Lai… - Frontiers in …, 2022 - frontiersin.org
Ehlers-Danlos syndrome (EDS) is a rare, genetically variable, heterogenous group of
(currently recognized) thirteen connective tissue disorders characterized by skin …
(currently recognized) thirteen connective tissue disorders characterized by skin …
Extracellular matrix is an important component of limbal stem cell niche
H Mei, S Gonzalez, SX Deng - Journal of functional biomaterials, 2012 - mdpi.com
Extracellular matrix plays an important role in stem cell niche which maintains the
undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to …
undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to …