Hepatitis C virus (HCV) remains a global problem, despite advances in treatment. The low
cost and high benefit of vaccines have made them the backbone of modern public health …

Despite 20 years of research, a vaccine to prevent hepatitis C virus (HCV) infection has not
been developed. A vaccine to prevent HCV will need to induce broadly reactive immunity …

Plant or microbial lectins are known to exhibit potent antiviral activities against viruses with
glycosylated surface proteins, yet the mechanism (s) by which these carbohydrate-binding …

For a long time, the lack of an appropriate cell culture system has hampered the study of
neutralizing antibody responses against hepatitis C virus (HCV). However, the last decade …

Natural cross-protective immunity is induced after spontaneous clearance of primary
hepatitis C virus (HCV) infection. Although this suggests that effective prophylactic vaccines …

Hepatitis C virus (HCV), an enveloped positive-sense single-stranded RNA virus, can cause
chronic and end-stage liver diseases. Approximately 185 million people worldwide are …

Hepatitis C virus (HCV) infection with associated chronic liver diseases is a major health
problem worldwide. Here, we designed hepatitis B virus (HBV) small surface antigen …

In spite of the high variability of its sequence, hepatitis C virus (HCV) envelope glycoprotein
E2 contains several conserved regions. In this study, we explored the structural and …

The hepatitis C virus (HCV) core protein (HCVcp) is the most highly conserved protein
encoded by the HCV genome, and its N-terminal domain (NTDHCVcp) plays a crucial role in …

Amino-acid coevolution can be referred to mutational compensatory patterns preserving the
function of a protein. Viral envelope glycoproteins, which mediate entry of enveloped viruses …