Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …

“Amphotericin B acts through pore formation at the cell membrane after binding to
ergosterol” is an accepted dogma about the action mechanism of this antifungal, and this …

The development of an effective oral therapeutics is an immediate need for the control and
elimination of visceral leishmaniasis (VL). We exemplify the preparation and optimization of …

Visceral leishmaniasis (VL) is a serious parasitic disease causing considerable mortality
and major disability in the Indian subcontinent. It is most neglected tropical disease …

This mini-review focuses on leishmanicidal drugs that were sourced from small molecules
previously approved for other diseases. The mechanisms of action of these molecules are …

Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …

Objectives Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine
transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of …

Introduction: Among the drugs in clinical use for the treatment of leishmaniases,
amphotericin B (AmB) is the most effective and has been the most extensively studied for the …

Leishmaniases are infectious diseases caused by an intracellular protozoan in humans by
20 different species of Leishmania among more than 53 species. There are at least twelve …

Despite the advancement of new anti-leishmanials, amphotericin B (AmB) prevails as one of
the most potent agent in the treatment of visceral leishmaniasis (VL), a neglected tropical …