Metastasis of tumor cells from primary sites of malignancy to neighboring stromal tissue or
distant localities entails in several instances, but not in every case, the epithelial …

Rho family GTPases are critical regulators of cellular functions that play important roles in
cancer progression. Aberrant activity of Rho small G-proteins, particularly Rac1 and their …

Background As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …

Abstract Paired-box 6 (PAX6) is an important transcription factor required for the function of
human neuroectodermal epithelial tissues. Previous studies have suggested that it is also …

Abstract Background: Circular RNAs (circRNAs) have been reported as the competing
endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs) implicating in the initiation …

Colorectal cancer (CRC) is one of the leading cancers worldwide, accounting for high
morbidity and mortality. The mechanisms governing tumor growth and metastasis in CRC …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

Rationale: Triple-negative breast cancer (TNBC) is characterized by the absence of
estrogen receptor alpha (ER-α), human epidermal growth factor receptor 2 (HER2) and …

The epithelial-mesenchymal transition (EMT) is an acknowledged cellular transition process
in which epithelial cells acquire mesenchymal-like properties that endow cancer cells with …

E-cadherin is well known as a growth and invasion suppressor and belongs to the large
cadherin family. Loss of E-cadherin is widely known as the hallmark of epithelial-to …