Drug repositioning: Progress and challenges in drug discovery for various diseases
Y Hua, X Dai, Y Xu, G Xing, H Liu, T Lu, Y Chen… - European Journal of …, 2022 - Elsevier
Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …
Niclosamide: Beyond an antihelminthic drug
W Chen, RA Mook Jr, RT Premont, J Wang - Cellular signalling, 2018 - Elsevier
Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of
people worldwide. However recent studies have indicated that niclosamide may have broad …
people worldwide. However recent studies have indicated that niclosamide may have broad …
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug
The rapid development of new anticancer drugs that are safe and effective is a common goal
shared by basic scientists, clinicians and patients. The current review discusses one such …
shared by basic scientists, clinicians and patients. The current review discusses one such …
Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice
H Tao, Y Zhang, X Zeng, GI Shulman, S Jin - Nature medicine, 2014 - nature.com
Abstract Type 2 diabetes (T2D) has reached an epidemic level globally. Most current
treatments ameliorate the hyperglycemic symptom of the disease but are not effective in …
treatments ameliorate the hyperglycemic symptom of the disease but are not effective in …
Feedback activation of STAT3 as a cancer drug-resistance mechanism
C Zhao, H Li, HJ Lin, S Yang, J Lin, G Liang - Trends in pharmacological …, 2016 - cell.com
Signal transducer and activator of transcription 3 (STAT3) plays crucial roles in several
cellular processes such as cell proliferation and survival, and has been found to be …
cellular processes such as cell proliferation and survival, and has been found to be …
Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature
CD Mohan, S Rangappa, HD Preetham… - Seminars in cancer …, 2022 - Elsevier
Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …
Transcription factor STAT3 as a novel molecular target for cancer prevention
Signal Transducers and Activators of Transcription (STATs) are a family of transcription
factors that regulate cell proliferation, differentiation, apoptosis, immune and inflammatory …
factors that regulate cell proliferation, differentiation, apoptosis, immune and inflammatory …
Drug repositioning: a machine-learning approach through data integration
Existing computational methods for drug repositioning either rely only on the gene
expression response of cell lines after treatment, or on drug-to-disease relationships …
expression response of cell lines after treatment, or on drug-to-disease relationships …
Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with …
Radiotherapy significantly improves the therapeutic outcomes and survival of breast cancer
patients. However, the acquired resistance to this therapeutic modality is a major clinical …
patients. However, the acquired resistance to this therapeutic modality is a major clinical …
Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?
JD Beebe, JY Liu, JT Zhang - Pharmacology & therapeutics, 2018 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) controls many biological
processes including differentiation, survival, proliferation, and angiogenesis. In normal …
processes including differentiation, survival, proliferation, and angiogenesis. In normal …