The mediodorsal thalamus: an essential partner of the prefrontal cortex for cognition

S Parnaudeau, SS Bolkan, C Kellendonk - Biological psychiatry, 2018 - Elsevier
Deficits in cognition are a core feature of many psychiatric conditions, including
schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome …

The mediodorsal thalamus in executive control

M Wolff, MM Halassa - Neuron, 2024 - cell.com
Executive control, the ability to organize thoughts and action plans in real time, is a defining
feature of higher cognition. Classical theories have emphasized cortical contributions to this …

Thalamic circuits for independent control of prefrontal signal and noise

A Mukherjee, NH Lam, RD Wimmer, MM Halassa - Nature, 2021 - nature.com
Interactions between the mediodorsal thalamus and the prefrontal cortex are critical for
cognition. Studies in humans indicate that these interactions may resolve uncertainty in …

Detection of schizophrenia using hybrid of deep learning and brain effective connectivity image from electroencephalogram signal

S Bagherzadeh, MS Shahabi, A Shalbaf - Computers in Biology and …, 2022 - Elsevier
Detection of mental disorders such as schizophrenia (SZ) through investigating brain
activities recorded via Electroencephalogram (EEG) signals is a promising field in …

[HTML][HTML] The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function

M Cleal, BD Fontana, DC Ranson, SD McBride… - Behavior research …, 2021 - Springer
Numerous neurodegenerative and psychiatric disorders are associated with deficits in
executive functions such as working memory and cognitive flexibility. Progress in developing …

Resting-state functional connectivity and psychotic-like experiences in childhood: results from the adolescent brain cognitive development study

NR Karcher, KJ O'Brien, S Kandala, DM Barch - Biological psychiatry, 2019 - Elsevier
Abstract Background Psychotic-like experiences (PLEs) during childhood are associated
with greater risk of developing a psychotic disorder (and other mental disorders) …

Transcutaneous auricular vagus nerve stimulation (taVNS) for migraine: an fMRI study

Y Zhang, Y Huang, H Li, Z Yan, Y Zhang… - Regional Anesthesia & …, 2021 - rapm.bmj.com
Background Dysfunction of the thalamocortical connectivity network is thought to underlie
the pathophysiology of the migraine. This current study aimed to explore the thalamocortical …

[HTML][HTML] Regulation of prefrontal patterning and connectivity by retinoic acid

M Shibata, K Pattabiraman, B Lorente-Galdos… - Nature, 2021 - nature.com
The prefrontal cortex (PFC) and its connections with the mediodorsal thalamus are crucial
for cognitive flexibility and working memory and are thought to be altered in disorders such …

Thalamocortical organoids enable in vitro modeling of 22q11. 2 microdeletion associated with neuropsychiatric disorders

D Shin, CN Kim, J Ross, KM Hennick, SR Wu… - Cell Stem Cell, 2024 - cell.com
Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to
study the mechanisms by which abnormalities emerge in the context of the 22q11. 2 …

Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function

LJ Benoit, ES Holt, L Posani, S Fusi, AZ Harris… - Nature …, 2022 - nature.com
Impaired cortical maturation is a postulated mechanism in the etiology of
neurodevelopmental disorders, including schizophrenia. In the sensory cortex, activity …