The therapeutic potential of carbon monoxide

R Motterlini, LE Otterbein - Nature reviews Drug discovery, 2010 - nature.com
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …

Sickle cell disease: renal manifestations and mechanisms

KA Nath, RP Hebbel - Nature Reviews Nephrology, 2015 - nature.com
Sickle cell disease (SCD) substantially alters renal structure and function, and causes
various renal syndromes and diseases. Such diverse renal outcomes reflect the uniquely …

Biological signaling by carbon monoxide and carbon monoxide-releasing molecules

R Motterlini, R Foresti - American Journal of Physiology …, 2017 - journals.physiology.org
Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …

Exhaled breath biomarker sensing

A Vasilescu, B Hrinczenko, GM Swain… - Biosensors and …, 2021 - Elsevier
This goal of this minireview is to introduce the reader to the area of research concerned with
exhaled breath analysis for the purpose of detecting abnormal levels of physiologically …

Use of carbon monoxide as a therapeutic agent: promises and challenges

R Foresti, MG Bani-Hani, R Motterlini - Intensive Care Medicine, 2008 - Springer
As a by-product of heme catabolism by the heme oxygenase system, carbon monoxide (CO)
has been neglected for many years, and only recently has its role as an essential signaling …

Recent progress of exhaled gas‐based diagnosis based on field effect transistor sensors

G Lu, T Ji, S He, F Ai, L Yan, J Hu - Advanced Functional …, 2024 - Wiley Online Library
Exhaled breath‐based disease diagnosis is an ancient technique, and the application of this
technique is rapidly developing for disease quick testing, such as viral infection, asthma …

Cardiovascular biomarkers in exhaled breath

FS Cikach Jr, RA Dweik - Progress in cardiovascular diseases, 2012 - Elsevier
With each breath that we exhale, thousands of molecules are expelled in our breath, giving
individuals a “breath-print” that can tell a lot about them and their state of health. Breath …

Human breath odors and their use in diagnosis

CL Whittle, S Fakharzadeh, J Eades… - Annals of the New York …, 2007 - Wiley Online Library
Humans emit a complex array of volatile and nonvolatile molecules that are influenced by an
individual's genetics, health, diet, and stress. Olfaction is the most ancient of our distal …

Bioinorganic systems responsive to the diatomic gases O2, NO, and CO: From biological sensors to therapy

LG de Franca Lopes, FSG Júnior, AKM Holanda… - Coordination Chemistry …, 2021 - Elsevier
The diatomic molecules, O 2, NO and CO, have had a myriad of roles in biology. Due to this,
nature has developed many sensing proteins to perceive and respond to changes in the …

Endogenous carbon monoxide production in disease

EO Owens - Clinical biochemistry, 2010 - Elsevier
Carbon monoxide (CO) in tissues and cells can originate from inhalation of CO or
endogenously. Endogenous production, carboxyhemoglobin (COHb) formation, and …