Over the past two decades, the development and application of ynamide chemistry have
received more and more attention. Ynamides have proven to be versatile reagents for …

Ynamides are among the most powerful building blocks in organic synthesis and have
become invaluable starting materials for the construction of multifunctional compounds and …

Triflimide (HNTf2) is a commercially available and highly versatile super Brønsted acid.
Owing to its strong acidity as well as good compatibility with organic solvents, it has been …

Conspectus Umpolung, a term describing the reversal of innate polarity, has become an
indispensable tool to unlock new chemical space by overcoming the limitations of natural …

Gold-catalyzed intermolecular alkyne oxidation by an N–O bond oxidant has proven to be a
powerful method in organic synthesis during the past decade, because this approach would …

A suite of flexible and chemoselective methods for the transition-metal-free oxidation of
amides to α-keto amides and α-hydroxy amides is presented. These highly valuable motifs …

Keteniminium ions have been demonstrated to be remarkably useful and versatile reactive
intermediates in chemical synthesis. These unique heterocumulenes are pivotal …

Much contemporary organic synthesis relies on transformations that are driven by the
intrinsic, so‐called “natural”, polarity of chemical bonds and reactive centers. The design of …

A new approach for the synthesis of 1, 4-dicarbonyl compounds is reported. Chemoselective
activation of amide carbonyl functionality and subsequent umpolung via N-oxide addition …

Since the beginning of this century, homogeneous gold‐catalyzed alkyne transformations
have been an active area of research in pursuit of developing efficient synthetic …