Abstract Cardiac cytochrome P450 2J2 (CYP2J2) metabolizes endogenous polyunsaturated
fatty acid, arachidonic acid (AA), to bioactive regioisomeric epoxyeicosatrienoic acid (EET) …

Flubromazolam is a triazole benzodiazepine with high potency and long‐lasting central
nervous system depressant effects; however, limited data about its pharmacokinetics are …

Metabolism of most pharmaceutical drugs occurs in the liver. In drug metabolism, enzymes
convert drugs to highly water-soluble metabolites to facilitate excretion from the body. Thus …

Abstract Cytochrome P450 (CYP450) enzymes, which are widely distributed and pivotal in
various biochemical reactions, catalyze diverse processes such as hydroxylation …

Atypical kinetics are observed in metabolic reactions catalyzed by cytochrome P450
enzymes (P450). Yet, this phenomenon is regarded as experimental artifacts in some …

An automated in-capillary assay requiring very small quantities of reagents was developed
for performing in vitro cytochrome P450 (CYP450) drug metabolism studies. The approach is …

Extracts, subfractions, isolated anthocyanins and procyanidins, and two phenolic acids from
aronia [Aronia melanocarpa] were investigated for their CYP3A4 inhibitory effects, using …

Data from in vitro drug metabolism studies with recombinant enzyme systems are frequently
used to predict human drug metabolism in vivo. However, for the CYP3A probe substrate …

In our previous study, panaxytriol (PXT) was shown to enhance midazolam (MDZ) 1′-
hydroxylation significantly but to inhibit MDZ 4-hydroxylation. To explore the underlying …

There are many factors which are known to cause variability in human in vitro enzyme
kinetic data. Factors such as the source of enzyme and how it was prepared, the genetics …