Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

Excessive intake of sugar: An accomplice of inflammation

X Ma, F Nan, H Liang, P Shu, X Fan, X Song… - Frontiers in …, 2022 - frontiersin.org
High sugar intake has long been recognized as a potential environmental risk factor for
increased incidence of many non-communicable diseases, including obesity, cardiovascular …

Understanding the tumor immune microenvironment (TIME) for effective therapy

M Binnewies, EW Roberts, K Kersten, V Chan… - Nature medicine, 2018 - nature.com
The clinical successes in immunotherapy have been both astounding and at the same time
unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical …

Food allergy

H Renz, KJ Allen, SH Sicherer, HA Sampson… - Nature reviews Disease …, 2018 - nature.com
Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options

RA Al-Alawi, JH Al-Mashiqri, JSM Al-Nadabi… - Frontiers in plant …, 2017 - frontiersin.org
Many plants, including some of the commonly consumed herbs and spices in our daily food,
can be safely and effectively used to prevent and/or treat some health concerns. For …

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

D Michalovich, N Rodriguez-Perez, S Smolinska… - Nature …, 2019 - nature.com
In order to improve targeted therapeutic approaches for asthma patients, insights into the
molecular mechanisms that differentially contribute to disease phenotypes, such as obese …

Nutritional and biological characteristics of the date palm fruit (Phoenix dactylifera L.)–A review

MI Hussain, M Farooq, QA Syed - Food Bioscience, 2020 - Elsevier
The date palm (Phoenix dactylifera L.) is a popular perennial fruit tree cultivated worldwide,
especially in West Asia and North Africa. Its fruit (date) is equally liked around the globe …

Therapeutic potential of ectopic olfactory and taste receptors

SJ Lee, I Depoortere, H Hatt - Nature Reviews Drug Discovery, 2019 - nature.com
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …

The nutrition‐gut microbiome‐physiology axis and allergic diseases

C McKenzie, J Tan, L Macia… - Immunological reviews, 2017 - Wiley Online Library
Dietary and bacterial metabolites influence immune responses. This raises the question
whether the increased incidence of allergies, asthma, some autoimmune diseases …

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

DF Quail, OC Olson, P Bhardwaj, LA Walsh… - Nature cell …, 2017 - nature.com
Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis
within tissue microenvironments. Given the correlation between obesity and relative risk of …