Development and Clinical Applications of Therapeutic Cancer Vaccines with Individualized and Shared Neoantigens

Q Hao, Y Long, Y Yang, Y Deng, Z Ding, L Yang, Y Shu… - Vaccines, 2024 - mdpi.com
Neoantigens, presented as peptides on the surfaces of cancer cells, have recently been
proposed as optimal targets for immunotherapy in clinical practice. The promising outcomes …

A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens

S Gupta, N Sgourakis - bioRxiv, 2024 - biorxiv.org
Peptides presented by class I major histocompatibility complex (MHC-I) proteins provide
biomarkers for therapeutic targeting using T cell receptors (TCRs), TCR-mimicking …

Advancing Prediction of MHC-Peptide Complex Structures through Enhanced AlphaFold Fine-Tuning

K Dmytro - 2024 - er.ucu.edu.ua
Protein structure prediction plays a pivotal role in understanding biological pro-cesses, with
a particular emphasis on Major Histocompatibility Complex (MHC)-peptide complexes due …