The expanding amyloid family: Structure, stability, function, and pathogenesis
The hidden world of amyloid biology has suddenly snapped into atomic-level focus,
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
Protein condensation diseases: therapeutic opportunities
M Vendruscolo, M Fuxreiter - Nature communications, 2022 - nature.com
Condensed states of proteins, including liquid-like membraneless organelles and solid-like
aggregates, contribute in fundamental ways to the organisation and function of the cell …
aggregates, contribute in fundamental ways to the organisation and function of the cell …
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
Prion-like domains (PLDs) can drive liquid-liquid phase separation (LLPS) in cells. Using an
integrative biophysical approach that includes nuclear magnetic resonance spectroscopy …
integrative biophysical approach that includes nuclear magnetic resonance spectroscopy …
How do intrinsically disordered protein regions encode a driving force for liquid–liquid phase separation?
Highlights•Not all IDRs undergo liquid–liquid phase separation.•IDRs are not necessary for
protein phase separation.•A stickers-and-spacers framework helps conceptualizing IDR …
protein phase separation.•A stickers-and-spacers framework helps conceptualizing IDR …
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
Liquid–liquid phase separation and its mechanistic role in pathological protein aggregation
WM Babinchak, WK Surewicz - Journal of molecular biology, 2020 - Elsevier
Liquid–liquid phase separation (LLPS) of proteins underlies the formation of membrane-less
organelles. While it has been recognized for some time that these organelles are of key …
organelles. While it has been recognized for some time that these organelles are of key …
Aging can transform single-component protein condensates into multiphase architectures
A Garaizar, JR Espinosa, JA Joseph… - Proceedings of the …, 2022 - National Acad Sciences
Phase-separated biomolecular condensates that contain multiple coexisting phases are
widespread in vitro and in cells. Multiphase condensates emerge readily within …
widespread in vitro and in cells. Multiphase condensates emerge readily within …
Mutations linked to neurological disease enhance self-association of low-complexity protein sequences
Protein domains of low sequence complexity do not fold into stable, three-dimensional
structures. Nevertheless, proteins with these sequences assist in many aspects of cell …
structures. Nevertheless, proteins with these sequences assist in many aspects of cell …
Shear relaxation governs fusion dynamics of biomolecular condensates
Phase-separated biomolecular condensates must respond agilely to biochemical and
environmental cues in performing their wide-ranging cellular functions, but our …
environmental cues in performing their wide-ranging cellular functions, but our …
Minimalist design of an intrinsically disordered protein-mimicking scaffold for an artificial membraneless organelle
Liquid–liquid phase separation (LLPS) is an emerging and universal mechanism for
intracellular organization, particularly, by forming membraneless organelles (MLOs) hosting …
intracellular organization, particularly, by forming membraneless organelles (MLOs) hosting …