Aortic dissection continues to be responsible for significant morbidity and mortality, although
recent advances in medical data assimilation and in experimental and in silico models have …

Large aortic aneurysm and acute and chronic aortic dissection are pathologies of the aorta
requiring surgery. Recent advances in medical intervention have improved patient …

Constrained mixture models for soft tissue growth and remodeling have attracted increasing
attention over the last decade. They can capture the effects of the simultaneous presence of …

Experimental data and a suitable material model for human aortas with smooth muscle
activation are not available in the literature despite the need for developing advanced grafts; …

Background Mechanical homeostasis promotes proper aortic structure and function.
Pathological conditions may arise, in part, from compromised or lost homeostasis. There is …

In health, PVAT secretes anti-contractile factors that relax the underlying artery. PVAT's
contributions to vascular function include more than production of vasoactive substances …

The development of the vascular system was a critical step in the evolution of species. It
allowed organisms to meet the growing metabolic demands and opened the door for the …

In this paper, we investigate the progression of Ascending Thoracic Aortic Aneurysms
(ATAA) using a computational model of Growth and Remodeling (G&R) taking into account …

Vascular smooth muscle cells (VSMCs) can regulate arterial mechanics via contractile
activity in response to changing mechanical and chemical signals. Contractility is …

The precise role of smooth muscle cell contractility in elastic arteries remains unclear, but
accumulating evidence suggests that smooth muscle dysfunction plays an important role in …