Increasing cure rates of solid tumors by immune checkpoint inhibitors

W Ma, R Xue, Z Zhu, H Farrukh, W Song, T Li… - … Hematology & Oncology, 2023 - Springer
Immunotherapy has become the central pillar of cancer therapy. Immune checkpoint
inhibitors (ICIs), a major category of tumor immunotherapy, reactivate preexisting anticancer …

The emerging landscape of neo/adjuvant immunotherapy in renal cell carcinoma

P Dibajnia, LM Cardenas… - Human vaccines & …, 2023 - Taylor & Francis
Adjuvant and neoadjuvant therapies that reduce the risk of renal cell carcinoma (RCC)
recurrence remain an area of unmet need. Advances have been made in metastatic RCC …

The 2022 updated european association of urology guidelines on the use of adjuvant immune checkpoint inhibitor therapy for renal cell carcinoma

J Bedke, L Albiges, U Capitanio, RH Giles, M Hora… - European urology, 2023 - Elsevier
Abstract In KEYNOTE-564, adjuvant pembrolizumab, a PD-1 antibody, significantly
improved disease-free survival (DFS) in localised clear-cell renal cell carcinoma (ccRCC) …

High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpoints

AM Raghubar, NA Matigian, J Crawford… - npj Precision …, 2023 - nature.com
Perioperative immune checkpoint inhibitor (ICI) trials for intermediate high-risk clear cell
renal cell carcinoma (ccRCC) have failed to consistently demonstrate improved patient …

[HTML][HTML] Post nephrectomy management of localized renal cell carcinoma. From risk stratification to therapeutic evidence in an evolving clinical scenario

C Ciccarese, A Strusi, D Arduini, P Russo… - Cancer treatment …, 2023 - Elsevier
Standard treatment for localized non-metastatic renal cell carcinoma (RCC) is radical or
partial nephrectomy. However, after radical surgery, patients with stage II-III have a …

Impact of sex on the efficacy of immune checkpoint inhibitors in kidney and urothelial cancers: a systematic review and meta-analysis

T Yanagisawa, T Kawada, F Quhal, K Bekku… - World Journal of …, 2023 - Springer
Purpose To analyze and summarize the efficacy of immune checkpoint inhibitor (ICI) alone
or in combination therapy for renal cell carcinoma (RCC) and urothelial carcinoma (UC) …

Top advances of the year: Genitourinary cancer

F Jackson‐Spence, M Young, C Sweeney, T Powles - Cancer, 2023 - Wiley Online Library
There have been significant advances in the treatment of urology cancers, with a number of
practice‐changing treatments. There is now greater clarity on the role of the use of …

Role of perioperative immunotherapy in localized renal cell carcinoma

J Kaur, G Patil, DM Geynisman… - … Advances in Medical …, 2023 - journals.sagepub.com
Immunotherapy has proven effective in metastatic renal cell carcinoma (RCC). The current
standard of treatment in localized RCC is partial or complete nephrectomy. However, after …

Adjuvant therapy options in renal cell carcinoma—targeting the metastatic cascade

KN Fitzgerald, RJ Motzer, CH Lee - Nature Reviews Urology, 2023 - nature.com
Localized renal cell carcinoma (RCC) is primarily managed with nephrectomy, which is
performed with curative intent. However, disease recurs in~ 20% of patients. Treatment with …

Current approaches in surgical and immunotherapy-based management of renal cell carcinoma with tumor thrombus

MM Tabbara, J González, M Martucci, G Ciancio - Biomedicines, 2023 - mdpi.com
Renal cell carcinoma (RCC) accounts for 2–3% of all malignant disease in adults, with 30%
of RCC diagnosed at locally advanced or metastatic stages of disease. A form of locally …