The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

Lipid risk factors for cardiovascular disease depend in part on lifestyle, but optimum control
of lipids often demands additional measures. Low-density lipoprotein (LDL) doubtless …

Bempedoic acid is a new cholesterol-lowering drug, which has recently received US FDA
and EMA approval. This drug targets lipid and glucose metabolism as well as inflammation …

Introduction ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, being the main
source of acetyl-Coenzyme A, an important precursor for fatty acid, cholesterol, and …

Importance Adenosine triphosphate citrate lyase (ACLY) is a key regulatory enzyme of
glucose metabolism, cholesterol and fatty acid synthesis, and the inflammatory cascade …

Lipid metabolism is a critical component in preserving homeostasis and health, and lipids
are significant chemicals involved in energy metabolism in living things. With the growing …

Atherosclerotic cardiovascular disease poses a significant global health issue, with
dyslipidemia standing out as a major risk factor. In recent decades, lipid-lowering therapies …

Itaconate is a mitochondrial metabolite, produced in high amounts by macrophages and
monocytes of mice and humans upon activation by several inflammatory stimuli. In 2013, the …

Abstract Background and aims Bempedoic Acid (BA) is a novel Lipid-Lowering Therapy
(LLT). We performed a systematic review and meta-analysis to assess the efficacy and …

Atherosclerotic heart disease is the leading cause of mortality and morbidity in the USA. Low
density lipoprotein (LDL) has been the target for many hypolipidemic agents to modify …