Parkinson's disease

BR Bloem, MS Okun, C Klein - The Lancet, 2021 - thelancet.com
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

Prodromal Parkinson disease subtypes—key to understanding heterogeneity

D Berg, P Borghammer, SM Fereshtehnejad… - Nature Reviews …, 2021 - nature.com
In Parkinson disease (PD), pathological processes and neurodegeneration begin long
before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal …

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson's disease

VTE Aho, MC Houser, PAB Pereira, J Chang… - Molecular …, 2021 - Springer
Background Previous studies have reported that gut microbiota, permeability, short-chain
fatty acids (SCFAs), and inflammation are altered in Parkinson's disease (PD), but how these …

Cognitive decline in Parkinson disease

D Aarsland, B Creese, M Politis… - Nature Reviews …, 2017 - nature.com
Dementia is a frequent problem encountered in advanced stages of Parkinson disease (PD).
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …

Brain-first versus gut-first Parkinson's disease: a hypothesis

P Borghammer… - Journal of Parkinson's …, 2019 - content.iospress.com
Parkinson's disease (PD) is a highly heterogeneous disorder, which probably consists of
multiple subtypes. Aggregation of misfolded alpha-synuclein and propagation of these …

A clinicopathological approach to the diagnosis of dementia

FM Elahi, BL Miller - Nature Reviews Neurology, 2017 - nature.com
The most definitive classification systems for dementia are based on the underlying
pathology which, in turn, is categorized largely according to the observed accumulation of …

Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment

S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Fatigue in Parkinson's disease: a systematic review and meta‐analysis

M Siciliano, L Trojano, G Santangelo… - Movement …, 2018 - Wiley Online Library
We conducted a systematic review and meta‐analysis aimed at establishing robust
prevalence estimates and identifying clinical correlates of fatigue in PD. From 2,459 titles …

Nonmotor features of Parkinson's disease subtypes

C Marras, KR Chaudhuri - Movement Disorders, 2016 - Wiley Online Library
Parkinson's disease is highly heterogeneous in early clinical features and later outcomes.
This makes classifying subgroups of PD relevant to clinical research and practice …

Natural history of pure autonomic failure: AU nited S tates prospective cohort

H Kaufmann, L Norcliffe‐Kaufmann… - Annals of …, 2017 - Wiley Online Library
Objective To define the clinical features and biomarkers that predict which patients with pure
autonomic failure will develop Parkinson disease, dementia with Lewy bodies, or multiple …