Pharmacotherapy for erectile dysfunction: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015)

K Hatzimouratidis, A Salonia, G Adaikan… - The journal of sexual …, 2016 - academic.oup.com
Introduction Treatment of erectile dysfunction is based on pharmacotherapy for most
patients. Aim To review the current data on pharmacotherapy for erectile dysfunction based …

PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer

A Das, D Durrant, FN Salloum, L Xi… - Pharmacology & …, 2015 - Elsevier
Abstract The phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra™),
vardenafil (Levitra™), and tadalafil (Cialis™) have been developed for treatment of erectile …

Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis

A Tsertsvadze, HA Fink, F Yazdi… - Annals of internal …, 2009 - acpjournals.org
Background: Erectile dysfunction (ED) is a common male sexual disorder. The relative
benefits and harms of pharmacologic therapies for ED, as well as the value of hormonal …

Efficacy of tadalafil once daily in men with diabetes mellitus and erectile dysfunction

D Hatzichristou, M Gambla, E Rubio‐Aurioles… - Diabetic …, 2008 - Wiley Online Library
Aims Erectile dysfunction (ED) is a common comorbidity in men with diabetes mellitus.
Tadalafil 10 or 20 mg taken on demand is efficacious and safe for men with diabetes and …

Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: a pilot study

A Aversa, E Greco, R Bruzziches, M Pili… - International journal of …, 2007 - nature.com
Men with erectile dysfunction (ED) frequently have a disproportionate burden of comorbid
vascular disorders including atherosclerotic disease. We investigated whether scheduled …

The endothelial cell in health and disease: its function, dysfunction, measurement and therapy

BG Schwartz, C Economides, GS Mayeda… - International journal of …, 2010 - nature.com
Endothelial cells have numerous endocrine functions and contribute to a variety of
processes, including penile erection and vasodilation. Endothelial dysfunction is associated …

Therapy of endocrine disease: effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis

D Santi, E Giannetta, AM Isidori, C Vitale… - European journal of …, 2015 - academic.oup.com
Objective Diabetes mellitus (DM) is associated with endothelial dysfunction, reducing nitric
oxide-dependent vasodilation, and increasing production of pro-inflammatory factors …

The triad: erectile dysfunction-endothelial dysfunction-cardiovascular disease

C Vlachopoulos, N Ioakeimidis… - Current …, 2008 - ingentaconnect.com
Endothelial dysfunction is an important process in the development of atherosclerotic
cardiovascular disease, while it is also a major pathophysiological mechanism underlying …

The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis

CU Osondu, B Vo, ET Oni, MJ Blaha… - Vascular …, 2018 - journals.sagepub.com
Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) and CVD
mortality. However, the relationship between ED and subclinical CVD is less clear. We …

Non-invasive diagnostic tools for investigating endothelial dysfunction

L Ghiadoni, D Versari, C Giannarelli… - Current …, 2008 - ingentaconnect.com
The endothelium is not merely a barrier but it plays a key role in the maintenance of vascular
homeostasis. A dysfunctional endothelium is an early marker of the development of …