Super-refractory status epilepticus is defined as status epilepticus that continues or recurs
24 h or more after the onset of anaesthetic therapy, including those cases where status …

Sleep is universal in animals, but its specific functions remain elusive. We propose that
sleep's primary function is to allow individual neurons to perform prophylactic cellular …

The function of sleep remained one of largest enigmas of neuroscience for most of the 20th
century. However in recent years different evidence has accumulated in support of a critical …

An open challenge in consciousness research is understanding how neural functions are
altered by pathological loss of consciousness. To maintain consciousness, the brain needs …

Objective Deep hypothermia induces 'burst suppression'(BS), an electroencephalogram
pattern with low-voltage 'suppressions' alternating with high-voltage 'bursts'. Current …

Status epilepticus refractory to first-line and second-line antiepileptic treatments challenges
neurologists and intensivists as mortality increases with treatment refractoriness and seizure …

Background The volatile anesthetic isoflurane may exert a rapid and long-lasting
antidepressant effect in patients with medication-resistant depression. The mechanism …

Objective To characterize the amount of EEG suppression achieved in refractory status
epilepticus (RSE) patients treated with pharmacologically-induced coma (PIC). Methods We …

Nonconvulsive status epilepticus (NCSE) in adults represents a constellation of conditions
producing ongoing ictal impairment with myriad clinical presentations. These may vary from …

The diagnosis and management of disorders of consciousness in children continue to
present a clinical, research, and ethical challenge. Though the practice guidelines for …