Cellular pathways that repair chromosomal double-strand breaks (DSBs) have pivotal roles
in cell growth, development and cancer. These DSB repair pathways have been the target of …

DNA double-strand breaks require repair or risk corrupting the language of life. To ensure
genome integrity and viability, multiple DNA double-strand break repair pathways function in …

Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-
prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation …

DNA double strand breaks (DSB) are cytotoxic lesions that can lead to genome
rearrangements and genomic instability, which are hallmarks of cancer. The two main DSB …

The Rad51/RecA family of recombinases perform a critical function in typical repair of
double-strand breaks (DSBs): strand invasion of a resected DSB end into a homologous …

Use of synthetic genomics to design and build 'big'DNA has revolutionized our ability to
answer fundamental biological questions by employing a bottom-up approach …

The industrially important non-conventional yeast Komagataella phaffii suffers from low rates
of homologous recombination, making site specific genetic engineering tedious. Therefore …

Microhomology-mediated end joining (MMEJ) is a highly mutagenic pathway to repair
double-strand breaks (DSBs). MMEJ was thought to be a backup pathway of homologous …

Synthetic Genomics focuses on the construction of rationally designed chromosomes and
genomes and offers novel approaches to study biology and to construct synthetic cell …

Background Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder caused by
mutations in the ataxia telangiectasia mutated (ATM) gene. AT patients manifest …