Negative and ambisense RNA viruses are the causative agents of important human
diseases such as influenza, measles, Lassa fever, and Ebola hemorrhagic fever. The viral …

Research on filoviruses has historically focused on the highly pathogenic ebola-and
marburgviruses. Indeed, until recently, these were the only two genera in the filovirus family …

Paramyxoviruses represent a family of RNA viruses causing significant human diseases.
These include measles virus, the most infectious virus ever reported, in addition to …

The respiratory syncytial virus (RSV) RNA polymerase, constituted of a 250 kDa large (L)
protein and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities …

Nonsegmented negative-stranded (NNS) RNA viruses, among them the virus that causes
rabies (RABV), include many deadly human pathogens. The large polymerase (L) proteins …

Junin virus (JUNV) causes Argentine hemorrhagic fever, a debilitating human disease of
high mortality rates and a great risk to public health worldwide. Studying the L protein that …

Mononegaviruses, such as Ebola virus, encode an L (large) protein that bears all the
catalytic activities for replication/transcription and RNA capping. The C-terminal conserved …

Nipah virus (NiV) is a non-segmented, negative-strand (NNS) RNA virus, belonging to
Paramyxoviridae. The RNA polymerase complex, composed of large (L) protein and …

Measles virus (MeV) and all Paramyxoviridae members rely on a complex polymerase
machinery to ensure viral transcription and replication. Their polymerase associates the …

As for all non-segmented negative RNA viruses, rabies virus has its genome packaged in a
linear assembly of nucleoprotein (N), named nucleocapsid. The formation of new …