Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth,
reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a …

MRI has enhanced our capacity to understand variations in brain structure and function
conferred by the genome. We identified 60 studies that report associations between DNA …

Depression is a prevalent and complex psychiatric syndrome. Epigenetic mechanisms
bridge the genetic and environmental factors that contribute to the pathophysiology of …

While genetic variants have been reported to be associated with obsessive-compulsive
disorder (OCD), the small effect sizes suggest that epigenetic mechanisms such as DNA …

This systematic review examines the genetic and epigenetic factors associated with resting-
state functional connectivity (RSFC) in healthy human adult brains across the lifespan, with a …

Background Most antidepressants have been developed on the basis of the monoamine
deficiency hypothesis of depression, in which neuronal serotonin (5-HT) plays a key role. 5 …

Background Studies in adult depressed patients have indicated that altered DNA
methylation patterns at genes related to serotonin and HPA axis functioning (eg, SLC6A4 …

Several studies have examined associations between peripheral DNA methylation patterns
of the serotonin transporter gene (SLC6A4) promoter and symptoms of depression and …

Environmental factors can influence gene expression via epigenetic modifications such as
DNA methylation. DNA methylation levels of regulatory regions in Hypothalamo-Pituitary …

Background Genetic and epigenetic variations of the serotonin transporter gene (SLC6A4)
have been related to the etiology of depression. The 5-HTTLPR polymorphism at the …