Antifungal drugs: New insights in research & development

AM Nicola, P Albuquerque, HC Paes… - Pharmacology & …, 2019 - Elsevier
The need for better antifungal therapy is commonly accepted in view of the high mortality
rates associated with systemic infections, the low number of available antifungal classes …

[HTML][HTML] Fungal vaccines, mechanism of actions and immunology: A comprehensive review

S Nami, R Mohammadi, M Vakili, K Khezripour… - Biomedicine & …, 2019 - Elsevier
Fungal infections include a wide range of opportunistic and invasive diseases. Two of four
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …

[HTML][HTML] Imunologia da paracoccidioidomicose

MRP Fortes, HA Miot, CS Kurokawa… - Anais brasileiros de …, 2011 - SciELO Brasil
Paracoccidioidomicose é a mais prevalente micose sistêmica na América Latina, em
pacientes imunocompetentes, sendo causada pelo fungo dimórfico Paracoccidioiddes …

Application of anti-fungal vaccines as a tool against emerging anti-fungal resistance

R Kumar, V Srivastava - Frontiers in Fungal Biology, 2023 - frontiersin.org
After viruses and bacteria, fungal infections remain a serious threat to the survival and well-
being of society. The continuous emergence of resistance against commonly used anti …

Fungal vaccine development: State of the art and perspectives using Immunoinformatics

MM Inácio, ALE Moreira, VRM Cruz-Leite, K Mattos… - Journal of Fungi, 2023 - mdpi.com
Fungal infections represent a serious global health problem, causing damage to health and
the economy on the scale of millions. Although vaccines are the most effective therapeutic …

Activity and in vivo tracking of Amphotericin B loaded PLGA nanoparticles

ACO Souza, AL Nascimento… - European journal of …, 2015 - Elsevier
The development of biocompatible polymeric nanoparticles has become an important
strategy for optimizing the therapeutic efficacy of many classical drugs, as it may expand …

Antibodies to Combat Fungal Infections: Development Strategies and Progress

AA Rabaan, AH Alfaraj, A Alshengeti, A Alawfi… - Microorganisms, 2023 - mdpi.com
The finding that some mAbs are antifungal suggests that antibody immunity may play a key
role in the defense of the host against mycotic infections. The discovery of antibodies that …

Intranasal vaccine using P10 peptide complexed within chitosan polymeric nanoparticles as experimental therapy for paracoccidioidomycosis in murine model

S Rodrigues Dos Santos Junior… - Journal of Fungi, 2020 - mdpi.com
Paracoccidioidomycosis (PCM) is a granulomatous fungal disease caused by the dimorphic
fungal species of Paracoccidioides, which mainly affects the lungs. Modern strategies for the …

Immunotherapy of fungal infections

K Datta, M Hamad - Immunological investigations, 2015 - Taylor & Francis
Fungal organisms are ubiquitous in the environment. Pathogenic fungi, although relatively
few in the whole gamut of microbial pathogens, are able to cause disease with varying …

New advances in the development of a vaccine against paracoccidioidomycosis

LR Travassos, CP Taborda - Frontiers in Microbiology, 2012 - frontiersin.org
Paracoccidioidomycosis (PCM) is an endemic Latin American mycosis caused by
Paracoccidioides brasiliensis and also by the recently described P. lutzii. The systemic …