Halogenated antimicrobial agents to combat drug-resistant pathogens
Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …
abilities of conventional antibiotics to combat pathogenic microbes. The history of …
The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules
Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as
they display vast biological activities. Recent efforts concerning the preparation of oxindole …
they display vast biological activities. Recent efforts concerning the preparation of oxindole …
Indole-based derivatives as potential antibacterial activity against methicillin-resistance Staphylococcus aureus (MRSA)
HL Qin, J Liu, WY Fang, L Ravindar… - European journal of …, 2020 - Elsevier
Antibacterial-resistance speaks to an overall alarm, particularly in regards to the flare-up of
methicillin-resistance Staphylococcus aureus (MRSA), a classic reason for genuine skin and …
methicillin-resistance Staphylococcus aureus (MRSA), a classic reason for genuine skin and …
Recent strategies in the synthesis of spiroindole and spirooxindole scaffolds
S Nasri, M Bayat, F Mirzaei - Topics in Current Chemistry, 2021 - Springer
Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in
drug design processes. Significant attention has been directed at obtaining molecules …
drug design processes. Significant attention has been directed at obtaining molecules …
The development of biologically important spirooxindoles as new antimicrobial agents
YT Yang, JF Zhu, G Liao, HJ Xu… - Current Medicinal …, 2018 - ingentaconnect.com
Background: Antibiotic resistance is one of the biggest threats to global health today, leading
to higher medical costs and increased mortality. Because of the emergence and rapid …
to higher medical costs and increased mortality. Because of the emergence and rapid …
Engaging isatins in multicomponent reactions (MCRs)–easy access to structural diversity
Multicomponent reactions (MCRs) are a valuable tool in diversity‐oriented synthesis. Its
application to privileged structures is gaining relevance in the fields of organic and …
application to privileged structures is gaining relevance in the fields of organic and …
Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles
R Javahershenas, A Makarem, KD Klika - RSC advances, 2024 - pubs.rsc.org
Spiro heterocycle frameworks are a class of organic compounds that possesses unique
structural features making them highly sought-after targets in drug discovery due to their …
structural features making them highly sought-after targets in drug discovery due to their …
Recent synthetic strategies of spiro-azetidin-2-one,-pyrrolidine,-indol (one) and-pyran derivatives-a review
Spiro-heterocycles have received special attention in medicinal chemistry because of their
promising biological activity. Over the years, many synthetic methodologies have been …
promising biological activity. Over the years, many synthetic methodologies have been …
Microwave produced 8-methyl-1, 2, 4, 8-tetraazaspiro [4.5] dec-2-en-3-amine derivatives: Their in vitro and in silico analysis
Compound 1 is formed by a microwave-assisted multicomponent reaction of 1-
methylpiperidin-4-one, 2-amino-4-methoxy-6-methyl-1, 3, 5-triazine, and thiosemicarbazide …
methylpiperidin-4-one, 2-amino-4-methoxy-6-methyl-1, 3, 5-triazine, and thiosemicarbazide …
An efficient three-component synthetic protocol for the synthesis of structurally diverse spiroannulated benzothiazolopyrimidines catalyzed by l-proline in aqueous …
An environmentally sustainable domino protocol has been presented to synthesize
structurally diverse spiro [benzothiazolo [3, 2-a] pyrimidine-4, 3′-indolines. The synthetic …
structurally diverse spiro [benzothiazolo [3, 2-a] pyrimidine-4, 3′-indolines. The synthetic …