Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association
This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
Genetics of congenital heart disease
K Williams, J Carson, C Lo - Biomolecules, 2019 - mdpi.com
Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …
Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis
Single-cell RNA sequencing is a powerful tool to study developmental biology but does not
preserve spatial information about tissue morphology and cellular interactions. Here, we …
preserve spatial information about tissue morphology and cellular interactions. Here, we …
Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages
Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …
embryogenesis and neonatal stages. To date, several groups have used single-cell …
Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms
Congenital heart disease (CHD) is the most common type of birth defect and is both a
significant pediatric and adult health problem, in light of a growing population of survivors …
significant pediatric and adult health problem, in light of a growing population of survivors …
Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease
Background Pulmonary arterial hypertension (PAH) is a rare disease characterized by
distinctive changes in pulmonary arterioles that lead to progressive pulmonary arterial …
distinctive changes in pulmonary arterioles that lead to progressive pulmonary arterial …
Diverse epigenetic mechanisms of human disease
E Brookes, Y Shi - Annual review of genetics, 2014 - annualreviews.org
Epigenetic control of gene expression programs is essential for normal organismal
development and cellular function. Abrogation of epigenetic regulation is seen in many …
development and cellular function. Abrogation of epigenetic regulation is seen in many …
Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
Cardiac regeneration may revolutionize treatment for heart failure but endogenous
progenitor-derived cardiomyocytes in the adult mammalian heart are few and pre-existing …
progenitor-derived cardiomyocytes in the adult mammalian heart are few and pre-existing …
The programming of cardiovascular disease
KL Thornburg - Journal of developmental origins of health and …, 2015 - cambridge.org
In spite of improving life expectancy over the course of the previous century, the health of the
US population is now worsening. Recent increasing rates of type 2 diabetes, obesity and …
US population is now worsening. Recent increasing rates of type 2 diabetes, obesity and …
MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus
F Quintero-Rivera, QJ Xi… - Human molecular …, 2015 - academic.oup.com
Cardiac left ventricular outflow tract (LVOT) defects represent a common but heterogeneous
subset of congenital heart disease for which gene identification has been difficult. We …
subset of congenital heart disease for which gene identification has been difficult. We …