Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain
Microglia actively survey the brain microenvironment and play essential roles in sculpting
synaptic connections during brain development. While microglial functions in the adult brain …
synaptic connections during brain development. While microglial functions in the adult brain …
Chronic deep cerebellar stimulation promotes long-term potentiation, microstructural plasticity, and reorganization of perilesional cortical representation in a rodent …
Control over postinjury CNS plasticity is a major frontier of science that, if conquered, would
open new avenues for treatment of neurological disorders. Here we investigate the …
open new avenues for treatment of neurological disorders. Here we investigate the …
The ventral hippocampus, but not the dorsal hippocampus is critical for learned approach‐avoidance decision making
A Schumacher, E Vlassov, R Ito - Hippocampus, 2016 - Wiley Online Library
The resolution of an approach‐avoidance conflict induced by ambivalent information
involves the appraisal of the incentive value of the outcomes and associated stimuli to …
involves the appraisal of the incentive value of the outcomes and associated stimuli to …
Porous silicon nanoparticles targeted to the extracellular matrix for therapeutic protein delivery in traumatic brain injury
Traumatic brain injury (TBI) is a major cause of disability and death among children and
young adults in the United States, yet there are currently no treatments that improve the long …
young adults in the United States, yet there are currently no treatments that improve the long …
Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma
K Morioka, Y Marmor, JA Sacramento, A Lin, T Shao… - Scientific reports, 2019 - nature.com
Polytraumatic injuries, specifically long bone fracture and traumatic brain injury (TBI),
frequently occur together. Clinical observation has long held that TBI can accelerate fracture …
frequently occur together. Clinical observation has long held that TBI can accelerate fracture …
Chronic 30-Hz deep cerebellar stimulation coupled with training enhances post-ischemia motor recovery and peri-infarct synaptophysin expression in rodents
AG Machado, J Cooperrider, HT Furmaga… - …, 2013 - journals.lww.com
BACKGROUND: Over 500 000 Americans have strokes every year, making stroke the
leading cause for disability in the United States and in the industrialized world. New …
leading cause for disability in the United States and in the industrialized world. New …
Red blood cell microparticles limit hematoma growth in intracerebral hemorrhage
Background: Spontaneous intracerebral hemorrhage (sICH) is the deadliest stroke subtype
with no effective therapies. Limiting hematoma expansion is a promising therapeutic …
with no effective therapies. Limiting hematoma expansion is a promising therapeutic …
The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents
HH Chan, ND Mathews, H Khanna, N Mandava… - Experimental …, 2024 - Elsevier
Despite great advances in acute care and rehabilitation, stroke remains the leading cause of
motor impairment in the industrialized world. We have developed a deep brain stimulation …
motor impairment in the industrialized world. We have developed a deep brain stimulation …
Lateral cerebellar nucleus stimulation promotes motor recovery and suppresses neuroinflammation in a fluid percussion injury rodent model
Background Many traumatic brain injury (TBI) survivors live with persistent disability from
chronic motor deficits despite contemporary rehabilitation services, underscoring the need …
chronic motor deficits despite contemporary rehabilitation services, underscoring the need …
Orthotopic meningioma rat model exhibits morphological and immunohistochemical congruency and epigenetic concordance with benign primary patient-derived …
MS Andersen, B Halle, M Wirenfeldt, JK Petersen… - Scientific reports, 2024 - nature.com
Meningiomas are the most common primary central nervous system tumor. Clinical trials
have failed to support effective medical treatments, despite initially promising animal studies …
have failed to support effective medical treatments, despite initially promising animal studies …