The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Advances in genomic technologies have led to a wealth of information identifying genetic
polymorphisms in membrane transporters, specifically how these polymorphisms affect drug …

A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …

Importance High-risk infants, defined as newborns with substantial neonatal-perinatal
morbidities, often undergo multiple procedures and require prolonged intubation, resulting …

Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

A large number of nutrients and bioactive ingredients found in milk play an important role in
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …

Psychiatric and substance use disorders inflict major public health burdens worldwide. Their
widespread burden is compounded by a dearth of effective treatments, underscoring a dire …

The interaction between drugs and various transporters is one of the decisive factors that
affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter …

A considerable number of drugs and/or their metabolites are excreted by the kidneys
through glomerular filtration and active renal tubule secretion via transporter proteins …

Poppy seeds are obtained from the opium poppy (Papaver somniferum L.). They are used
as food and to produce edible oil. The opium poppy plant contains narcotic alkaloids such …